Having acknowledged that our active rational powers are limited, it is unsurprising that such powers would fail in certain hypothetical circumstances, tailored precisely to exploit those limitations, but when our limited powers are exercised in favorable circumstances, the Cartesian contends that this exercise has every right to count as yielding knowledge.
This doesn't, of itself, deal with the skeptical claim that we can't prove that we are not in an unfavorable circumstance; but, as she rightly says, the worry that we might be wrong is less pressing than the worry that we can't be right, to which it does provide a serious response.
(Cross-posted at Houyhnhnm Land)