Some dates are approximate; events for a year are not necessarily in order.
1260 Gherardo Segarelli begins preaching and gathering what would become the Apostolic Brethren, Segarelli's version of a mendicant order; Siena (Ghibelline) defeats Florence (Guelph) at the Battle of Montaperti
1268 Pope Clement IV dies and the papal conclave deadlocks between the French and the Italians
1271 The last major Crusade, under Edward Longshanks, makes some notable but very temporary gains in the Holy Land; Bl. Gregory X becomes Pope as a compromise candidate to break the deadlock (he is very surprised to be elected because he is not a bishop and is on crusade with Edward)
1272 Second Council of Lyon convoked in Lyon, France; St. Thomas Aquinas dies on his way to attend the council
1274 Second Council of Lyon restructures papal elections and forbids new mendicant orders without papal sanction; Rudolph I proclaimed Holy Roman Emperor; St. Bonaventure dies while attending the council
1276 Pope Gregory X dies and Bl. Innocent V becomes Pope; Pope Innocent V dies and Adrian V becomes Pope; Pope Adrian V dies and John XXI becomes Pope
1277 Pope John XXI dies and Nicholas III becomes Pope
1280 Pope Nicholas III dies and Martin IV becomes Pope, being crowned at Orvieto due to the hostility of the Romans to him
1282 Sicilian Vespers: a rebellion against French rule breaks out in Sicily, with the result that thousands of French are slaughtered; the Sicilians appeal to King Peter of Aragon for defense and the War of the Sicilian Vespers begins, plunging Europe into war
1284 Pope Martin IV declares the Aragonese Crusade against Peter of Aragon as part of the War of the Vespers, leading to civil war in Aragon
1285 Pope Martin IV dies (never having visited Rome during his pontificate) and Honorius IV becomes Pope
1287 Pope Honorius IV dies
1288 Nicholas IV becomes Pope (the first Franciscan Pope)
1291 Fra Dolcino joins the Apostolic Brethren
1292 Pope Nicholas IV dies
1294 Four Segarellians are burned at the stake and Gherardo Segarelli is imprisoned; St. Celestine V becomes Pope in July and abdicates in December; Boniface VIII becomes Pope and imprisons Celestine; Pope Celestine V welcomes the Fraticelli pf Angelo da Clareno but Pope Boniface VIII revokes their privileges
1296 Pope Boniface VIII declares the Fraticelli heretical
1298 Peter John Olivi dies
1300 Gherardo Segarelli burned at the stake in Parma; Fra Dolcino becomes the leader of the Apostolic Brethren; Pope Boniface VIII declares the first Jubilee Year
1301 Pope Boniface VIII issues the papal bull Ausculta Fili, requiring King Philip IV (the Fair) of France to do penance for intrusions on papal authority
1302 King Philip has the bull Ausculta Fili publicly burned in Paris; Pope Boniface VIII issues the papal bull Unam Sanctam, emphasizing papal supremacy; the Peace of Caltabellota ends the War of the Sicilian Vespers
1303 Pope Boniface VIII excommunicates King Philip the Fair; Pope Boniface VIII dies; Bl. Benedict XI becomes Pope
1304 The Dolcinians retreat to mountain fortresses, from which they conduct a guerilla compaign against the crusaders sent to rout them; Pope Benedict XI dies;
1305 Clement V is elected Pope, and refuses to go to Italy for his coronation, choosing Lyon instead; the Curia is moved to Poitiers
1307 Fra Dolcino and Margareta are burned at the stake; King Philip IV begins rounding up the Templars to avoid having to repay loans from them and to enrich his treasury with their assets; Bernard Gui begins his tenure as Inquisitor of Toulouse
1309 The papal curia is moved to Avignon: the Babylonian Captivity of the Papacy begins
1311 Under pressure from King Philip, Clement V convokes the Council of Vienne, which will suppress the Templars in the next year; Henry VII is crowned King of Italy in Milan
1312 Henry VII becomes Holy Roman Emperor
1313 Marsilius of Padua is rector of the University of Paris; Pope Clement V canonizes St. Celestine V
1314 Pope Clement V dies; John of Jandun begins publishing works of natural philosophy
1316 John XXII becomes Pope; Michael Cesena is elected minister general of the Franciscans
1317 Pope John XXII excommunicates Angelo da Clareno; Ubertino of Casale allowed to leave the Franciscan Order and become a Benedictine
1318 Pope John XXII excommunicates Ubertino of Casale
1320 The Shepherds' Crusade: a popular movement of reconquest takes fire in Normandy and leads to assaults on castles, priests, and Jews
1322 Ubertino of Casale summoned to Avignon and manages to do well there; the Franciscans declare in favor of the doctrine of the absolute poverty of Christ; Pope John XXII issues the bull Ad conditorem canonum renouncing claim over all property the Church held for the Franciscans, thus forcing them to have property
1323 Louis IV becomes Holy Roman Emperor and sends an army to defend Milan against Naples; Pope John XXII opposes his accession and begins canonical proceedings against him; Pope John XXII issues the bull Cum inter nonnullos, declaring heretical the position that Christ and the Apostles had no property; Bernard Gui finishes his tenure as Inquisitor of Toulouse, having had over 900 heresy convictions in his fifteen years as Inquisitor
1324 Marsilius of Padua writes Defensor Pacis, arguing for imperial supremacy over the Church; Louis issues the Sachsenhausen Appeal, accusing Pope John XXII of being a heretic for his views on the poverty of Christ; Pope John XXII excommunicates the Emperor
1325 Ubertino of Casale accused of heresy for defending the ideas of Peter Olivi
1327 Louis is crowned King of Italy in Milan; Pope John XXII excommunicates Marsilius of Padua and John of Jandun; Michael Cesena is summoned to Avignon over the dispute about the poverty of Christ; the events of Umberto Eco's The Name of the Rose begin
1328 Louis reaches Rome and crowns himself Emperor; he issues a proclamation declaring Pope John XXII deposed for reasons of heresy and installs Nicholas V as antipope; John of Jandun becomes part of the Imperial court; Michael Cesena and his advisors (including William of Ockham) flee Avignon and are excommunicated by Pope John XXII
1329 Pope John XXII excommunicates Nicholas V
1330 Nicholas V begs pardon of Pope John XXII in Avignon and is absolved, but remains under house arrest; ; Michael Cesena accuses Pope John XXII of heresy; the Franciscans expel Michael of Cesena from the Order; Bertrand de Turre becomes Vicar General of the Order
1331 Bernard Gui dies
1333 Nicholas V dies
1334 Benedict XII becomes Pope
1336 Pope Benedict XII issues the bull Benedictus Deus establishing the doctrine that the souls of the saints go to the reward on death
1337 Angelo da Clareno dies
1342 Michael of Cesena dies; Pope Benedict XII dies and Clement VI becomes Pope
1346 Pope Clement VI excommunicates King Louis IV again and puts his support behind Charles IV to replace him; reports of the Black Death in Asia begin to filter into Europe
1347 William of Ockham dies; the Black Death reaches Sicily; Louis IV dies and after a short period, Charles IV is the only serious claimant to be Holy Roman Emperor
1348 The Black Death reaches Genoa, Venice, and Pisa; from Pisa it spreads throughout Europe; Pope Clement VI begins to attend the sick in Avignon personally and issues the bull Quamvis perfidiam, condemning anyone who initiated violence against Jews because of accusations that they were to blame for the plague