Paolo Buonvino and Skin, "Renaissance". The opening title theme from Medici Masters of Florence, which was actually fairly good -- a decent balance between historical accuracy and what was required to make a story in the medium.
The Latin is from Wisdom 1:2, and means, "In simplicity of heart seek Him; for He is found by those who do not test Him." The saying, addressed to the rulers of the earth, is most often heard in combination with verse 1, which gives the title of a number of chants and polyphonic compositions, Diligite justitiam, "Love justice".